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COVID-19 Times: Impact on Information Generation and Data Sharing  [PDF]
Eden Rodríguez-Flores, Saúl Gómez-Manzo, Jaime Marcial-Quino, Roberto Arreguín-Espinosa, Eduardo Rodríguez-Bustamante
Advances in Internet of Things (AIT) , 2022, DOI: 10.4236/ait.2022.123005
Abstract: At the beginning of 2020, human activities were interrupted by a new virus, identified as SARS-CoV-2, which causes COVID-19 disease. The scientific area was no exception: for a certain period, researchers around the world were forced to leave their laboratories and work remotely. There was a global necessity for finding alternatives focused on generating knowledge and publishing data, so repositories of scientific information, such as databases, represented strong support. In the specific case of life sciences, different strategies allowed rapid compilation of data and its sharing worldwide. Therefore, in this work, the impact of the SARS-CoV-2 pandemic on the amount of peer-reviewed and published papers during COVID-19 times was analyzed along with the role of databases. Our results pointed out that an increase in the number of papers belonging to different knowledge fields took place, with the medical field being the most significant. On the other hand, the complete genome of the new virus was sequenced, and repositories were created with sufficient data for monitoring, preventing, and controlling its dissemination. This was the case for the generation of vaccines in addition to potential candidates for drugs against COVID-19. However, although in 2021, vaccines allowed us to gradually return to our activities, databases and the generation of other repositories remain a key point for facing new strains and adapting
Structural and Functional Perturbation of Giardia lamblia Triosephosphate Isomerase by Modification of a Non-Catalytic, Non-Conserved Region
Gloria Hernández-Alcántara, Alfredo Torres-Larios, Sergio Enríquez-Flores, Itzhel García-Torres, Adriana Castillo-Villanueva, Sara T. Méndez, Ignacio de la Mora-de la Mora, Saúl Gómez-Manzo, Angélica Torres-Arroyo, Gabriel López-Velázquez, Horacio Reyes-Vivas, Jesús Oria-Hernández
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0069031
Abstract: Background We have previously proposed triosephosphate isomerase of Giardia lamblia (GlTIM) as a target for rational drug design against giardiasis, one of the most common parasitic infections in humans. Since the enzyme exists in the parasite and the host, selective inhibition is a major challenge because essential regions that could be considered molecular targets are highly conserved. Previous biochemical evidence showed that chemical modification of the non-conserved non-catalytic cysteine 222 (C222) inactivates specifically GlTIM. The inactivation correlates with the physicochemical properties of the modifying agent: addition of a non-polar, small chemical group at C222 reduces the enzyme activity by one half, whereas negatively charged, large chemical groups cause full inactivation. Results In this work we used mutagenesis to extend our understanding of the functional and structural effects triggered by modification of C222. To this end, six GlTIM C222 mutants with side chains having diverse physicochemical characteristics were characterized. We found that the polarity, charge and volume of the side chain in the mutant amino acid differentially alter the activity, the affinity, the stability and the structure of the enzyme. The data show that mutagenesis of C222 mimics the effects of chemical modification. The crystallographic structure of C222D GlTIM shows the disruptive effects of introducing a negative charge at position 222: the mutation perturbs loop 7, a region of the enzyme whose interactions with the catalytic loop 6 are essential for TIM stability, ligand binding and catalysis. The amino acid sequence of TIM in phylogenetic diverse groups indicates that C222 and its surrounding residues are poorly conserved, supporting the proposal that this region is a good target for specific drug design. Conclusions The results demonstrate that it is possible to inhibit species-specifically a ubiquitous, structurally highly conserved enzyme by modification of a non-conserved, non-catalytic residue through long-range perturbation of essential regions.
A Novel Phospholipase A2 Isolated from Palythoa caribaeorum Possesses Neurotoxic Activity
Abel Santamaría,Ana Laura Colín-González,Benjamín Velasco-Bejarano,Fernando Lazcano-Pérez,Jaime Marcial-Quino,Karen Helena Díaz de la Vega-Casta？eda,Miguel Cuevas-Cruz,Norma A. Valdez-Cruz,Roberto Arreguín-Espinosa,Saúl Gómez-Manzo,Sergio A. Román-González,Ulises Hernández-Guzmán
- , 2019, DOI: 10.3390/toxins11020089
Abstract: Zoanthids of the genus Palythoa are distributed worldwide in shallow waters around coral reefs. Like all cnidarians, they possess nematocysts that contain a large diversity of toxins that paralyze their prey. This work was aimed at isolating and functionally characterizing a cnidarian neurotoxic phospholipase named A2-PLTX-Pcb1a for the first time. This phospholipase was isolated from the venomous extract of the zoanthid Palythoa caribaeorum. This enzyme, which is Ca2+-dependent, is a 149 amino acid residue protein. The analysis of the A2-PLTX-Pcb1a sequence showed neurotoxic domain similitude with other neurotoxic sPLA2′s, but a different catalytic histidine domain. This is remarkable, since A2-PLTX-Pcb1a displays properties like those of other known PLA2 enzymes
Pool of Biological Resources for Potential Applications in Solid State Fermentation Obtained from a Forest Plantation of Pinus pseudostrobus Lindl, Mexico  [PDF]
E. Rodríguez-Bustamante, E. Rodríguez-Flores, F. Rojas-García, A. S. Callejas-Iberri, L. M. Gallardo-Roldán, S. Gómez-Manzo, J. Marcial-Quino, M. L. Macías-Rubalcava, F. Lazcano-Pérez, R. Arreguín-Espinosa
Advances in Microbiology (AiM) , 2016, DOI: 10.4236/aim.2016.614096
Abstract: A forest plantation, product of the reforestation of pine trees, represented a pool of biological resources for the implementation of a solid state fermentation process. The trees were identified as Pinus pseudostrobus Lindl from which lignocellulosic material in the form of pine needles was collected. Soil fungi, responsible for plant litter decomposition, were cultured at laboratory conditions and tested for their ability to grow on cellulose and hemicellulose as the sole carbon sources. A fungal strain, belonging to the genus Penicillium, was selected for growing it on pine needles as the substrate in a solid state culture. After following the culture for six days, the newly isolated strain exhibited a much higher capacity for spore production and holocellulose degradation, compared to a purchased strain of Penicillium chrysogenum and two control conditions. This work marks the beginning of future studies focused on commercial applications and represents the first report of a biotechnological process based on pine needles and their degradation by an ascomycetes species belonging to the genus Penicillium.
Low Serum Tryptophan Levels as an Indicator of Global Cognitive Performance in Nondemented Women over 50 Years of Age
B. García-Juárez,B. Jiménez Herrera,B. Pineda,C. Ríos,D. González-Esquivel,D. Ramírez-Ortega,G. Pérez de la Cruz,G. Roldán-Roldán,I. García Mu？oz,J. Marcial-Quino,L. A. Ramos-Chávez,L. Sánchez Chapul,P. Carrillo Mora,S. Gómez-Manzo,V. Pérez de la Cruz
- , 2018, DOI: 10.1155/2018/8604718
Abstract:
Propuesta para la pacificación del tráfico en la Ciudad Blanca, Universidad Nacional de Colombia, Bogotá D.C.
Ojeda Gómez Saúl
Ingeniería e Investigación , 2000,
Abstract: La Ciudad Blanca, o Ciudad Universitaria, como se la conoce desde tiempo atrás registra hechos de accidentalidad de tránsito que inquietan a su comunidad de estudiantes, docentes y empleados, dada las consecuencias que tales hechos acarrean a quienes en ella conviven a diario. Este artículo considera en primer lugar la situación aludida atrás, a la luz de la información suministrada al respecto por la división de Vigilancia y Seguridad de la Universidad. A continuación se intenta una aproximación a la causalidad presente en dicha situación y, por ultimo se presenta una propuesta de trabajo interfacultades, orientada a la pacificación del tráfico dentro de la Ciudad Blanca.
An Efficient Δ-Causal Distributed Algorithm for Synchronous Cooperative Systems in Unreliable Networks
Pomares Hernández, Saúl E.;López Domínguez, Eduardo;Rodríguez Gómez, Gustavo;
Computación y Sistemas , 2010,
Abstract: in cooperative systems causal ordering delivery has been used to resolve problems of coherency of type producer-consumer. causal order delivery is important for distributed systems since it allows an asynchronous execution to participants. when time delivery constraints are considered, ensuring causal delivery becomes more complex, as is the case for synchronous cooperative systems, such as telemedicine and teleimmersion. in these systems, the messages (units of data of continuous and discrete media) have an associated lifetime that determines the period of useful time in which the messages must be delivered. on the other hand, generally in these systems there is no time for retransmit them when messages are lost. causal order with time constraints has previously been addressed, and it is called δ-causal order. in this paper, we present an efficient δ-causal distributed algorithm for unreliable networks that is characterized by the use of a forward error correction (fec) scheme and a distributed method to calculate the message lifetime based on relative time points (i.e. no global time is used). we show the efficiency of our δ-causal algorithm in terms of the control information attached per message.
Primer registro del cacique mexicano (Cacicus melanicterus) en el estado de Tabasco, México
Sánchez Soto, Saúl;Gómez Martínez, Ulda Nury;
Huitzil , 2011,
Abstract: we report the first record of cacicus melanicterus in tabasco state, mexico. two males and two females, and one male and one female were observed on april 8th, 2007, and march 27th, 2011, respectively, in the locality of malpasito (17°20'40"n, 93°35'26"w), at the south of huimanguillo municipality.
Prolapso tubario poshisterectomía: Un caso raro de iatrogenia
Zighelboim,Itic; Kízer,Saúl; Gómez,Luis Gonzalo; Essenfeld,Harold;
Revista de Obstetricia y Ginecología de Venezuela , 2004,
Abstract: a case report of fallopian tube ampulla vaginal prolapsed after abdominal hysterectomy that caused vaginal discharge and dyspareunia.
Densidad estomática en hojas de Retrophyllum rospigliosii (Pilg.)
Hoyos Gómez Saúl E.,Rodríguez Ramírez Natalia
Acta Biológica Colombiana , 2005,
Abstract: En R. rospigliosii la mitad de sus hojas sufren una torsión (resupinación), exponiendo su envés ontogénico a la luz y el haz a la sombra. El objetivo de este trabajo fue establecer si la resupinación tiene consecuencias a nivel ecofisiológico y que por esa razón las hojas resupinadas difieran de las no resupinadas en características morfológicas como la densidad estomática. Se encontró que, contrario a lo que ocurre en la mayoría de las especies, los haces ontogénicos de R. rospigliosii presentan una mayor densidad estomática que el envés y que tal polarización de los estomas no cambia por la torsión que sufran las hojas. Se propone que la condición de resupinación representa ventajas evolutivas para R. rospigliosii en el manejo del recurso hídrico, teniendo en cuenta que la transpiración disminuye en el haz ontogénico por su menor exposición a la radiación solar, el viento y las temperaturas extremas en las regiones altoandinas, donde se distribuye. Esto representa menor pérdida de agua en las hojas resupinadas. Resultaría interesante revisar otras posibles implicaciones fisiológicas y anatómicas de las hojas de esta especie en función de su resupinación.
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